The tests of ZiS-22-52 half-truck began in September 1940. The design of this vehicle was based on mass-production cargo ZiS-5. According to the test results it was decided to begin mass production of this car after a minor revision under ZIS-22M mark. The issue of track began in summer 1941. But only 61 vehicle was produced before evacuation of the ZIS plant in October 1941.